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10.1186/s12974-019-1402-y J Neuroinflamm

One of the earliest and most damaging events is excitotoxicity, where oxygen and glucose deprivation lead to excessive release of glutamate and over-activation of NMDA and AMPA receptors, causing calcium influx and neuronal hyperexcitation (25)

Li Q, Han Y, Dy ABC, Hagerman RJ

These contrasting findings suggest that the mechanism of regulating intestinal inflammation by mTORC1 is multifarious, which may be dependent on whether mTORC1 activation is transient or constitutive