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Furthermore, in STZ-induced T2DM model rats, JUN protein expression was increased, and NRF2 expression was decreased in pancreatic tissues, potentially linking these changes to ferroptosis in T2DM-related -cell dysfunction [72]

doi: 10.1016/j.coi.2003.12.001

In clinical practice, weighing the therapeutic benefits against the potential adverse effects is crucial in individualizing treatment approaches for patients with PD