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Glycocalyx heparan sulfate cleavage promotes endothelial cell angiopoietin-2 expression by impairing shear stress-related AMPK/FoxO1 signaling

This is not a guaranteethe framework can be wrongbut it is better than guessing

This will reduce the protection provided by the HPA axis, attenuating immune and inflammatory changes, and leaving ME/CFS patients more vulnerable to minor stressors (429)