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By activating both receptors, tirzepatide reduces hunger, enhances blood sugar control, and boosts metabolismleading to more substantial weight loss than GLP-1 peptides alone

However, their growing popularity as cognitive enhancers raises concerns, particularly among older adults who use multiple medications, as this can increase the risk of adverse interactions (81)

A preliminary study has suggested that GLP1RAs may have positive effects on mood and could provide benefits to patients with mood disorders, such as depression (116)

due to congenital vitamin B12 transport disorders

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