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Excessive lipid peroxidation contributes to plasma membrane damage and further triggering multiple cell death modalities

MEVs are created through processes like nitrogen cavitation, where macrophage cell membranes are fragmented and reassembled into small, distinct vesicular units that retain the functional properties of their parent macrophages

10.1016/j.bcp.2020.114365 53 NoblancA.PeltierM.Damon-SoubeyrandC.KerchkoveN.ChaboryE.VernetP.et al (2012)

Heme is the prosthetic group for a number of proteins, including among others hemoglobin, myoglobin, mitochondrial cytochromes, microsomal cytochromes (including cytochrome P450), catalase, peroxidase, tryptophanpyrrolase, prostaglandin endoperoxide synthase, and the soluble form of guanylate cyclase

Prognostic and predictive epigenetic biomarkers in oncology