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For instance, Fe-MOF modified with pH-sensitive hydroxyapatite (HAp) and magnetic core (Fe 3 O 4 ) presented excellent biocompatibility and tumor targeting properties when it was used for the magnetic targeted drug delivery and pH-controlled drug release ( 3.2.4.3 Redox response of MOFs for targeted drug release The concentration of reducing agent glutathione (GSH) within tumor cells was more than 1 10 3 times that outside the cells and 4 times higher compared with inside ones