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Free Radic Biol Med 37(6):768784

The importance of selenium in human nutrition was documented in 1979, when Chinese scientists reported that selenium supplementation prevented the development of a cardiomyopathy known as Keshan disease in children living in low-selenium areas (4), and New Zealand workers reported a clinical response to selenium in a selenium-depleted patient (5)

doi: 10.1038/s41418-020-0528-x 151 LiuTZhuCChenXGuanGZouCShenSet al

Moreover, the active ingredients in Licorice, 18-Glycyrrhetinic acid, has shown anti-inflammatory effects by reducing IL-18 in fructose (FRU)-incubated HK2 cells and FRU-induced mice (30)

APOE 4 carriers have increased A plaque deposition and earlier onset of amyloid pathology than non-carriers, while APOE 2 carriers show delayed deposition and less A pathology [155159]