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Gabapentinoids, serotonin-norepinephrine reuptake inhibitors (SNRIs), sodium channel blockers, and tricyclic antidepressants have been suggested as the first approach for neuropathic pain in patients with DPN, and oral analgesics and lidocaine patches are also considered

Cytokines are pleiotropic glycoproteins produced by both peripheral immune cells and glial cells in the brain.1516 Cytokines usually have an important role in mediating immune signals and inflammatory processes in the peripheral system and in the brain

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As with any therapeutic agents, the potential for side effects associated with suppression of GH should be considered