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It is considered to be advantageous in patients with TB, as there is no evidence of TB occurrence or reactivation associated with its use (101)

Too much estrogen being metabolized through CYP1B1 into 4-OHE1(E2) and the estrogen quinones can potentially be bad if your body has slower phase II (COMT, GSTP1, GSTM1, NQO1) enzymes.[ref][ref] The connection between smoking and estrogen-related cancers: Smoking significantly increases the risk of breast cancer and prostate cancer

Third, we found potential publication bias for studies analyzing vitamin B12, vitamin D, and homocysteine, and this may confound findings of the meta-analysis