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& Breen, K

10.3389/fnmol.2015.00077 23

In murine studies, the probiotic strain Lactobacillus Rhamnosus has found to make positive changes to the GABA receptors in the brain which reduces stress hormones and leads to less depression and anxiety and was via signals from the gut to the brain via the vagus nerve

On the other hand, Akkermansia muciniphila can activate immune cells in the intestine, such as macrophages and dendritic cells, to secrete the anti-inflammatory cytokine IL-10 and inhibit the inflammatory response (Mei et al., 2024)