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Studies have identified distinct miRNA expression profiles for alcoholic and non-alcoholic fatty liver, with some experiments on mouse models showing that the Lieber-DeCarli alcohol diet induced the upregulation of 1% of miRNAs and the downregulation of 1%, while the methionine-choline-deficient (MCD) diet induced the upregulation of 3% and downregulation of 1% [91]

Taken together, these findings suggest that esculin targets several pathological mechanisms underlying impaired diabetic wound healingoxidative imbalance, persistent inflammation, defective collagen remodeling, and impaired angiogenesisand therefore represents a rational candidate for investigation in streptozotocin-induced diabetic wounds

Reaven GM, Chen YD, Golay A, Swislocki AL, Jaspan JB

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