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These advances may ultimately support immune-informed risk assessment and contribute to the gradual development of more individualized management strategies for RPL

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In recent years, in addition to its pyruvate kinase function, PKM2 has sparked considerable interest for its noncanonical function, which regulates gene expression as a transcription factor coactivator of Hif-1, -catenin, and p53 30,31,32 or phosphorylates proteins as a protein kinase 33,34,35,36

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Collectively, adequate SCFA, particularly butyrate, production by a eubiotic microbiota represents a key mechanism through which the gutbrain axis maintains redox balance and neuronal health