Mal-Propionyl-PEG6-Val-Cit-PAB(m-PEG4)-Exatecan Size:25mg Product Name Phthalimidinoglutarimide-C6-Br Synonyms Phthalimidinoglutarimide-4'-C6-Br

Product Name Phthalimidinoglutarimide-C6-Br Synonyms Phthalimidinoglutarimide-4'-C6-Br CAS Number n/a Related CAS Molecular Formula C19H23BrN2O3 Molecular Weight 407

ACS Chemical Biology 2020

O=C(N1CCNCC1)C1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC): 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

Product Name N'-Formylkynurenine Synonyms CAS Number 1022-31-7 Related CAS Molecular Formula C11H12N2O4 Molecular Weight 236

376 SMILES OC(=O)C1CCN(CC1)C1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Mal-Propionyl-PEG6-Val-Cit-PAB(m-PEG4)-Exatecan Size:25mg Product Name Phthalimidinoglutarimide-C6-Br Synonyms Phthalimidinoglutarimide-4'-C6-BrSOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG6 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I